Chronobiology of and Chronotherapy for Rheumatoid Arthritis
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چکیده
For instance, ICR mice, which were housed under standardized light-dark cycle conditions (lights-on and lights-off at 7:00 and 19:00, respectively) at a room temperature of 24 ± 1oC (range) and a relative humidity of 60 ± 10% (range) and were allowed free access to food and water displayed a circadian rhythm in their leukocyte counts with a peak at noon and a trough at midnight (Fig. 1). Many organisms display rhythms in various factors (Table 1). In humans, heart rate and blood pressure decline at night. We spend much of our time in a standing position during the day and sleep in a recumbent position at night. It is thought that the wake-sleep transition and endogenous circadian rhythms are responsible for the circadian rhythms in heart rate and blood pressure. Circadian rhythms also exist for the
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Modiied‐release Prednisone in Rheumatoid Arthritis: Rationale for Chronotherapy, Mechanistic Considerations, and Clinical Implications
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